Scientific Concept Note — Part 2
The final schedule may be adapted according to treatment duration, institutional capacity and participant availability.
Potential Outcome Domains
Substance Use
Craving, relapse and continued recovery.
Mental Health
Depression, anxiety and psychological distress.
Psychological Functioning
Emotional regulation, flexibility and coping.
Quality of Life
Physical, emotional and social well-being.
Cognitive Functioning
Attention, memory, decision-making and executive functioning.
Social Reintegration
Family relationships, employment and community participation.
Spirituality and Meaning
Values, belonging, meaning in life and spiritual resources.
Treatment Engagement
Retention, adherence, participation and follow-up.
Proposed Data Collection
Data collection may combine validated questionnaires, structured interviews, institutional records, participant-reported outcomes and qualitative interviews. Digital systems may support symptom monitoring, follow-up and participant engagement. Digital tools should support, not replace, professional care or direct clinical assessment.
Qualitative Research
Qualitative interviews may provide insight into recovery experiences, identity reconstruction, relationships, stigma, spirituality, treatment engagement and barriers to long-term recovery. Analysis should follow transparent and scientifically appropriate methods.
Ethics and Participant Protection
- ✦ Voluntary informed consent
- ✦ Right to withdraw
- ✦ Protection from coercion
- ✦ Confidentiality and data minimization
- ✦ Secure data storage
- ✦ Protection of vulnerable participants
- ✦ Independent ethical review
- ✦ Clear professional responsibilities
- ✦ Respect for cultural and religious diversity
Data Governance
The project should establish clear rules for data ownership, access, anonymization, storage, retention, analysis, authorship and publication. Brazilian institutions and professionals should participate in study governance, interpretation and scientific dissemination.
International Collaboration
Potential partners may contribute to study design, methodology, validated instruments, statistics, data management, ethics, neuroscience, neuropsychology, addiction medicine and cross-cultural analysis. Brazil should be treated as an active scientific partner and not merely as a participant-recruitment location.
International CollaborationFuture Research Perspective
The Observatory may create a scientific foundation for future research on preparation, integration, psychological mechanisms and psychedelic-assisted approaches. No interventional psychedelic research is included in the initial observational project. Any future study involving psychedelic substances would require qualified medical and academic leadership, ethical approval, regulatory authorization, suitable infrastructure and participant protection.
Potential Scientific Outputs
- ✦ Feasibility report
- ✦ Baseline population profile
- ✦ Longitudinal outcome analyses
- ✦ Relapse and adherence studies
- ✦ Qualitative publications
- ✦ Cross-cultural studies
- ✦ Conference presentations
- ✦ Professional training materials
- ✦ Future multicenter proposals
Proposed Development Phases
Academic, clinical and community partners.
Objectives, methods, instruments and governance.
Formal submission before recruitment.
Training, data collection and follow-up.
Interpretation, dissemination and future development.
Invitation to Scientific Dialogue
PSICODELIX welcomes dialogue with universities, hospitals, researchers, foundations and institutions interested in addiction recovery, community mental health, longitudinal research and cross-cultural cooperation.
The immediate objective is to refine the concept, identify qualified partners and develop a realistic pilot protocol.
Contact for Institutional Collaboration